Senescent alveolar macrophages promote early-stage lung tumorigenesis

Senescent cells play relevant but context-dependent roles during tumorigenesis. Here, in an oncogenic Kras-driven lung cancer mouse model, we found that senescent cells, specifically alveolar macrophages, accumulate early in neoplasia. These macrophages have upregulated expression of p16INK4a and Cx...

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Bibliographic Details
Published in:Cancer cell 2023-07, Vol.41 (7), p.1261-1275.e6
Main Authors: Prieto, Luis I., Sturmlechner, Ines, Graves, Sara I., Zhang, Cheng, Goplen, Nick P., Yi, Eunhee S., Sun, Jie, Li, Hu, Baker, Darren J.
Format: Article
Language:English
Subjects:
aging
alveolar macrophages
Animals
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
cytotoxic T cells
Humans
Lung - metabolism
Lung Neoplasms - genetics
Macrophages, Alveolar - metabolism
Mice
senolytic
Tumor Microenvironment
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