Structural Basis of Eukaryotic Cell-Cell Fusion

Cell-cell fusion proteins are essential in development. Here we show that the C. elegans cell-cell fusion protein EFF-1 is structurally homologous to viral class II fusion proteins. The 2.6 Å crystal structure of the EFF-1 trimer displays the same 3D fold and quaternary conformation of postfusion cl...

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Bibliographic Details
Published in:	Cell 2014-04, Vol.157 (2), p.407-419
Main Authors:	Pérez-Vargas, Jimena, Krey, Thomas, Valansi, Clari, Avinoam, Ori, Haouz, Ahmed, Jamin, Marc, Raveh-Barak, Hadas, Podbilewicz, Benjamin, Rey, Félix A.
Format:	Article
Language:	English
Subjects:	Amino Acid Sequence Animals Biochemistry, Molecular Biology Caenorhabditis elegans Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins Caenorhabditis elegans Proteins - chemistry Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Fusion crystal structure Crystallography, X-Ray Evolution, Molecular Giant Cells Giant Cells - metabolism Life Sciences Membrane Fusion Membrane Glycoproteins Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Models, Molecular Molecular Sequence Data Mutagenesis Polymerization Protein Structure, Tertiary Sequence Alignment Structural Biology Viral Fusion Proteins Viral Fusion Proteins - chemistry Viral Fusion Proteins - genetics Viral Fusion Proteins - metabolism
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