Coordinate regulation of the senescent state by selective autophagy

Cellular senescence is a complex stress response implicated in aging. Autophagy can suppress senescence but is counterintuitively necessary for full senescence. Although its anti-senescence role is well described, to what extent autophagy contributes to senescence establishment and the underlying me...

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Bibliographic Details
Published in:Developmental cell 2021-05, Vol.56 (10), p.1512-1525.e7
Main Authors: Lee, Yeonghyeon, Kim, Jaejin, Kim, Mi-Sung, Kwon, Yoojin, Shin, Sanghee, Yi, Hyerim, Kim, Hyeonkyeong, Chang, Moon Jong, Chang, Chong Bum, Kang, Seung-Baik, Kim, V. Narry, Kim, Jin-Hong, Kim, Jong-Seo, Elledge, Stephen J., Kang, Chanhee
Format: Article
Language:English
Subjects:
aging
autophagy
cellular senescence
inflammation
oxidative stress
proteostasis
regulated protein stability
selective autophagy
stress response
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