B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

B cells can present antigens to CD4+ T cells, but it is thought that dendritic cells (DCs) are the primary initiators of naive CD4+ T cell responses. Nanoparticles, including virus-like particles (VLPs), are attractive candidates as carriers for vaccines and drug delivery. Using RNA phage Qβ-derived...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Mass.), 2018-10, Vol.49 (4), p.695-708.e4
Main Authors:	Hong, Sheng, Zhang, Zhimin, Liu, Hongtao, Tian, Meijie, Zhu, Xiping, Zhang, Zhuqiang, Wang, Weihong, Zhou, Xuyu, Zhang, Fuping, Ge, Qing, Zhu, Bing, Tang, Hong, Hua, Zhaolin, Hou, Baidong
Format:	Article
Language:	English
Subjects:	Animals Antigen presentation Antigen Presentation - immunology antigen-presenting cell Antigen-presenting cells Antigen-Presenting Cells - immunology Antigens Antigens, Viral - chemistry Antigens, Viral - immunology APC B cells B-Lymphocytes - immunology CD4 antigen CD4+ T cells CD4-Positive T-Lymphocytes - immunology Cell activation Cell Differentiation - immunology Cell division Cell proliferation Cytokines - immunology Cytokines - metabolism Dendritic cells Drug delivery Drug delivery systems Gene expression Genomes Immune system Immunization Immunization - methods Immunological tolerance Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza Vaccines - immunology Initiators Lymphocytes Lymphocytes B Lymphocytes T Mice, Inbred C57BL Mice, Knockout Mice, Transgenic MyD88 nanoparticle Nanoparticles Nanoparticles - chemistry Phages Proteins Ribonucleic acid RNA RNA phages Statistical analysis T cell receptors T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Tfh Th1 TLR tolerance Toll-like receptor Toll-like receptors Toll-Like Receptors - immunology vaccine Vaccines Vaccines, Inactivated - immunology Viral infections virus-like particle Virus-like particles Viruses VLP
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