Cellular pathways influenced by protein arginine methylation: Implications for cancer

Arginine methylation is an influential post-translational modification occurring on histones, RNA binding proteins, and many other cellular proteins, affecting their function by altering their protein-protein and protein-nucleic acid interactions. Recently, a wealth of information has been gathered,...

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Bibliographic Details
Published in:	Molecular cell 2021-11, Vol.81 (21), p.4357-4368
Main Authors:	Xu, Jian, Richard, Stéphane
Format:	Article
Language:	English
Subjects:	Alternative Splicing Animals arginine Arginine - chemistry arginine methylation B7-H1 Antigen - metabolism cancer therapy Cell Communication Cell Line, Tumor CRISPR-Cas Systems DNA Damage DNA damage signaling DNA Repair drugs Enzyme Inhibitors - pharmacology Epigenesis, Genetic epigenetics Histones Humans Immune System immunotherapy Immunotherapy - methods Methylation Mice Mice, Knockout Neoplasms - metabolism post-translational modification pre-mRNA splicing PRMTs protein arginine methyltransferases Protein Processing, Post-Translational Protein-Arginine N-Methyltransferases - antagonists & inhibitors Protein-Arginine N-Methyltransferases - chemistry RNA RNA Splicing RNA, Messenger - metabolism S-adenosylmethionine Signal Transduction small-molecule inhibitors transcription
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