Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity

AKB48 and its fluorinated derivative 5F-AKB48 are synthetic cannabinoids (SCs) which have caused hospitalizations and deaths in human users. Abuse of SCs is dangerous because users may mistake them for natural cannabis, which is generally considered to be unlikely to elicit adverse effects. The pres...

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Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2020-08, Vol.195, p.172949-172949, Article 172949
Main Authors: Pinson, Anna, Yarbrough, Azure L., Bush, John M., Cabanlong, Christian V., Shoeib, Amal, Jackson, Bailey K., Fukuda, Saki, Gogoi, Jyoti, Fantegrossi, William E., McCain, Keith, Prather, Paul L., Fujiwara, Ryoichi, Radominska-Pandya, Anna
Format: Article
Language:English
Subjects:
Adamantane - analogs & derivatives
Adamantane - metabolism
Adamantane - toxicity
Adverse effects
Animals
Cannabinoid Receptor Antagonists - pharmacology
Cannabinoid receptors
Cytochrome P-450 CYP2D6 - genetics
Cytochrome P-450 CYP2D6 - metabolism
Cytochrome P-450 CYP3A - genetics
Cytochrome P-450 CYP3A - metabolism
Female
HPLC
Humans
Indazoles - metabolism
Indazoles - toxicity
Male
Metabolism
Mice
Mice, Inbred C57BL
Microsomes, Liver - drug effects
Microsomes, Liver - metabolism
Oxidation-Reduction - drug effects
P450 polymorphism
Polymorphism, Genetic
Protein Binding
Receptor, Cannabinoid, CB1 - agonists
Receptor, Cannabinoid, CB1 - metabolism
Recombinant Proteins - metabolism
Rimonabant - pharmacology
Sex Factors
Synthetic cannabinoids
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