Lipidomic analysis reveals significant lipogenesis and accumulation of lipotoxic components in ob/ob mouse organs

To further understand the role of lipogenesis and lipotoxicity in the development of obesity and diabetes, lipidomes of various organs from ob/ob mice and their wild type controls were analyzed by shotgun lipidomics at 10, 12, and 16 weeks of age. We observed that the amounts of fatty acyl (FA) chai...

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Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2018-09, Vol.136, p.161-169
Main Authors: Hayakawa, Jun, Wang, Miao, Wang, Chunyan, Han, Rowland H., Jiang, Zhen Y., Han, Xianlin
Format: Article
Language:English
Subjects:
Advanced Basic Science
Endocrinology & Metabolism
Lipidomics
Lipogenesis
Lipotoxicity
ob/ob Mice
Obesity
Shotgun lipidomics
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