Epigenetic deregulation of the COX pathway in cancer

Inflammation is a major cause of cancer and may condition its progression. The deregulation of the cyclooxygenase (COX) pathway is implicated in several pathophysiological processes, including inflammation and cancer. Although, its targeting with nonsteroidal antiinflammatory drugs (NSAIDs) and COX-...

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Bibliographic Details
Published in:Progress in lipid research 2012-10, Vol.51 (4), p.301-313
Main Authors: Cebola, Inês, Peinado, Miguel A.
Format: Article
Language:English
Subjects:
adverse effects
anti-inflammatory activity
biochemical pathways
Dinoprost - biosynthesis
Dinoprostone - biosynthesis
DNA methylation
Epigenesis, Genetic
epigenetics
Epoprostenol - biosynthesis
Gene regulation
Gene Silencing
genes
Histone modification
Humans
inflammation
Inflammation and cancer
neoplasm cells
Neoplasms - enzymology
Neoplasms - pathology
nonsteroidal anti-inflammatory agents
patients
Prostaglandin D2 - biosynthesis
prostaglandin synthase
Prostaglandin-Endoperoxide Synthases - genetics
Prostaglandin-Endoperoxide Synthases - metabolism
Prostaglandins
Signal Transduction
therapeutics
Thromboxane A2 - biosynthesis
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