Alvaradoins E−N, Antitumor and Cytotoxic Anthracenone C-Glycosides from the Leaves of Alvaradoa haitiensis

Bioactivity-directed fractionation of an extract of the leaves of Alvaradoa haitiensis, using the KB (human oral epidermoid carcinoma) cell line, led to the isolation and identification of 10 new anthracenone C-glycosides, alvaradoins E−N (1−10), along with the known compound chrysophanol (11). The...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-06, Vol.70 (6), p.954-961
Main Authors: Phifer, Sharnelle S, Lee, Dongho, Seo, Eun-Kyoung, Kim, Nam-Cheol, Graf, Tyler N, Kroll, David J, Navarro, Hernán A, Izydore, Robert A, Jiménez, Francisco, Garcia, Ricardo, Rose, William C, Fairchild, Craig R, Wild, Robert, Soejarto, Djaja D, Farnsworth, Norman R, Kinghorn, A. Douglas, Oberlies, Nicholas H, Wall, Monroe E, Wani, Mansukh C
Format: Article
Language:English
Subjects:
Alvaradoa haitiensis
alvaradoin
animal disease models
Animals
Anthracenes
Anthracenes - chemistry
Anthracenes - isolation & purification
Anthracenes - pharmacology
anthracenone
anticarcinogenic activity
Antineoplastic Agents, Phytogenic
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
chemical structure
chemistry
cultured cells
cytotoxicity
Dominican Republic
Drug Screening Assays, Antitumor
General pharmacology
glycosides
Humans
isolation & purification
KB Cells
Leukemia P388
Medical sciences
medicinal plants
mice
Models, Biological
Molecular Structure
Monosaccharides
Monosaccharides - chemistry
Monosaccharides - isolation & purification
Monosaccharides - pharmacology
Pharmacognosy. Homeopathy. Health food
pharmacology
Pharmacology. Drug treatments
Picramniaceae
Plant Leaves
Plant Leaves - chemistry
Plants, Medicinal
Plants, Medicinal - chemistry
Simaroubaceae
Simaroubaceae - chemistry
spectral analysis
Structure-Activity Relationship
structure-activity relationships
traditional medicine
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