A Hexacyclic ent-Trachylobane Diterpenoid Possessing an Oxetane Ring from Mitrephora glabra

Three new ent-trachylobane diterpenoids (1−3) were isolated and structures elucidated from Mitrephora glabra Scheff. (Annonaceae). Mitrephorone A (1) possesses a hexacyclic ring system with adjacent ketone moieties and an oxetane ring, both of which are unprecedented among trachylobanes. All compoun...

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Published in:	Organic letters 2005-12, Vol.7 (25), p.5709-5712
Main Authors:	Li, Chen, Lee, Dongho, Graf, Tyler N, Phifer, Sharnelle S, Nakanishi, Yuka, Burgess, Jason P, Riswan, Soedarsono, Setyowati, Fransisca M, Saribi, Achmad M, Soejarto, Djaja D, Farnsworth, Norman R, Falkinham, Joseph O, Kroll, David J, Kinghorn, A. Douglas, Wani, Mansukh C, Oberlies, Nicholas H
Format:	Article
Language:	English
Subjects:	Amphotericin B - pharmacology Annonaceae - chemistry Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Bacteria - drug effects Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Drug Screening Assays, Antitumor Humans Microbial Sensitivity Tests Molecular Structure Plants, Medicinal - chemistry Saccharomyces cerevisiae - drug effects Tumor Cells, Cultured
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