CD22 CAR T-cell therapy in refractory or relapsed B acute lymphoblastic leukemia

Despite worldwide promising clinical outcome of CD19 CAR-T therapy, relapse after this therapy is associated with poor prognosis and has become an urgent problem to be solved. We conducted a CD22 CAR T-cell therapy in 34 relapsed or refractory (r/r) B-ALL pediatric and adult patients who failed from...

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Bibliographic Details
Published in:	Leukemia 2019-12, Vol.33 (12), p.2854-2866
Main Authors:	Pan, Jing, Niu, Qing, Deng, Biping, Liu, Shuangyou, Wu, Tong, Gao, Zhiyong, Liu, Zhaoli, Zhang, Yue, Qu, Xiaomin, Zhang, Yanlei, Liu, Shaohui, Ling, Zhuojun, Lin, Yuehui, Zhao, Yongqiang, Song, Yanzhi, Tan, Xiyou, Zhang, Yan, Li, Zhihui, Yin, Zhichao, Chen, Bingzhen, Yu, Xinjian, Yan, Ju, Zheng, Qinlong, Zhou, Xuan, Gao, Jin, Chang, Alex H., Feng, Xiaoming, Tong, Chunrong
Format:	Article
Language:	English
Subjects:	13/109 13/21 13/31 42/44 45/23 45/77 45/90 45/91 692/308/575 692/699/1541/1990/283/2125 Acute lymphoblastic leukemia Adolescent Adult Antigens Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism B cells Biopsy Cancer Research CD19 antigen CD22 antigen Child Child, Preschool Combined Modality Therapy - adverse effects Combined Modality Therapy - methods Critical Care Medicine Cytokines Cytokines - metabolism Cytotoxicity, Immunologic Disease Management Diseases Female Follow-Up Studies Hematology Humans Immunotherapy, Adoptive - adverse effects Immunotherapy, Adoptive - methods Infant Intensive Internal Medicine Leukemia Lymphatic leukemia Lymphocytes T Male Medical colleges Medical prognosis Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Mutation Neurotoxicity Oncology Patients Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - etiology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - metabolism Relapse Remission Sialic Acid Binding Ig-like Lectin 2 - antagonists & inhibitors Sialic Acid Binding Ig-like Lectin 2 - metabolism T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism Therapy Transplantation Young Adult
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