Chemical biology of anticancer gold(iii) and gold(i) complexes

Gold complexes have recently gained increasing attention in the design of new metal-based anticancer therapeutics. Gold( iii ) complexes are generally reactive/unstable under physiological conditions via intracellular redox reactions, and the intracellular Au III to Au I reduction reaction has recen...

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Bibliographic Details
Published in:Chemical Society reviews 2015-12, Vol.44 (24), p.8786-881
Main Authors: Zou, Taotao, Lum, Ching Tung, Lok, Chun-Nam, Zhang, Jing-Jing, Che, Chi-Ming
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biology
cancer therapy
Cell Line, Tumor
Cell Proliferation - drug effects
drug therapy
Enzymes
ethane
Exchange
Fluorescence
Gold
Humans
Ligands
Molecular Structure
Neoplasms - drug therapy
Neoplasms - pathology
Organogold Compounds - chemistry
Organogold Compounds - pharmacology
oxidoreductases
Redox reactions
Reductases
thioredoxins
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