Oral Administration of a Dual Analog of Two Myasthenogenic T Cell Epitopes down-Regulates Experimental Autoimmune Myasthenia Gravis in Mice

Myasthenia gravis (MG) and experimental autoimmune MG (EAMG) are T cell-regulated, antibody-mediated autoimmune diseases. The major autoantigen in MG is the nicotinic acetylcholine receptor (AChR). Two peptides, representing sequences of the human AChR α -subunit, p195-212 and p259-271, were previou...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2000-02, Vol.97 (5), p.2168-2173
Main Authors: Paas-Rozner, Miri, Dayan, Molly, Paas, Yoav, Changeux, Jean-Pierre, Wirguin, Itzhak, Sela, Michael, Mozes, Edna
Format: Article
Language:English
Subjects:
Administration, Oral
Amino Acid Sequence
Animals
Antibodies
Antibody Specificity
Autoantigens - administration & dosage
Autoantigens - immunology
Autoantigens - therapeutic use
Biological Sciences
Cell lines
Cytokines
Cytokines - biosynthesis
Down-Regulation
Epitopes
Epitopes, T-Lymphocyte - administration & dosage
Epitopes, T-Lymphocyte - immunology
Epitopes, T-Lymphocyte - therapeutic use
Humans
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Myasthenia gravis
Myasthenia Gravis, Autoimmune, Experimental - drug therapy
Myasthenia Gravis, Autoimmune, Experimental - immunology
Oral administration
Peptides - immunology
Receptors, Nicotinic - administration & dosage
Receptors, Nicotinic - immunology
Receptors, Nicotinic - therapeutic use
Secretion
Symptoms
T lymphocytes
Vaccination
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