Differential methylation analysis for BS-seq data under general experimental design

Motivation: DNA methylation is an epigenetic modification with important roles in many biological processes and diseases. Bisulfite sequencing (BS-seq) has emerged recently as the technology of choice to profile DNA methylation because of its accuracy, genome coverage and higher resolution. Current...

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Bibliographic Details
Published in:Bioinformatics 2016-05, Vol.32 (10), p.1446-1453
Main Authors: Park, Yongseok, Wu, Hao
Format: Article
Language:English
Subjects:
Algorithms
Bioinformatics
bisulfites
Computational efficiency
Deoxyribonucleic acid
Design analysis
DNA Methylation
Epigenesis, Genetic
epigenetics
experimental design
Genome
Iterative algorithms
loci
Mathematical models
Methylation
Original Papers
regression analysis
Research Design
sequence analysis
Statistical methods
statistical models
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