Prospective identification of parasitic sequences in phage display screens

Phage display empowered the development of proteins with new function and ligands for clinically relevant targets. In this report, we use next-generation sequencing to analyze phage-displayed libraries and uncover a strong bias induced by amplification preferences of phage in bacteria. This bias fav...

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Bibliographic Details
Published in:Nucleic acids research 2014-02, Vol.42 (3), p.1784-1798
Main Authors: Matochko, Wadim L., Cory Li, S., Tang, Sindy K.Y., Derda, Ratmir
Format: Article
Language:English
Subjects:
Cell Surface Display Techniques
Data Interpretation, Statistical
Genomics
High-Throughput Nucleotide Sequencing
Peptide Library
Sequence Analysis, DNA
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