Disrupted‐in‐schizophrenia‐1 protects synaptic plasticity in a transgenic mouse model of Alzheimer’s disease as a mitophagy receptor

Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Accumulated damaged mitochondria, which are associated with impaired mitophagy, contribute to neurodegeneration in AD. We show levels of Disrupted‐in‐schizophrenia‐1 (DISC1), which is genetically associated with psychiat...

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Published in:	Aging cell 2019-02, Vol.18 (1), p.e12860-n/a
Main Authors:	Wang, Zhao‐Tao, Lu, Mei‐Hong, Zhang, Yan, Ji, Wen‐Li, Lei, Lei, Wang, Wang, Fang, Li‐Pao, Wang, Lu‐Wen, Yu, Fan, Wang, Ji, Li, Zhen‐Yu, Wang, Jian‐Rong, Wang, Ting‐Hua, Dou, Fei, Wang, Qin‐Wen, Wang, Xing‐Long, Li, Shao, Ma, Quan‐Hong, Xu, Ru‐Xiang
Format:	Article
Language:	English
Subjects:	Alzheimer Disease - complications Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Amino Acid Motifs Amino Acid Sequence Amyloid beta-Protein Precursor - metabolism Animals Autophagosomes - drug effects Autophagosomes - metabolism Autophagosomes - ultrastructure autophagy Brain Brain - metabolism Brain - pathology Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology Cognition Disorders - complications Cognition Disorders - physiopathology Cognitive ability Dendritic spines Disc1 protein Disease Models, Animal Disrupted‐in‐schizophrenia‐1 Down-Regulation - drug effects Genetic engineering HeLa Cells Humans Long-term potentiation Male Mental disorders Mice, Transgenic Microtubule-Associated Proteins - metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - ultrastructure Mitophagy Mitophagy - drug effects Models, Biological Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurodegeneration Neurodegenerative diseases Neuronal Plasticity - drug effects Original Presenilin 1 Protein Binding - drug effects Rodents Schizophrenia Synaptic plasticity Toxicity Transgenic mice
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