Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma

Androgen receptor (AR) signaling is considered to be crucial for the pathogenesis of hepatocellular carcinoma (HCC) with obvious sexual dimorphism. Pre‐mRNA processing factor 6 (PRPF6) was identified as a coactivator of AR. However, the molecular mechanism underlying the modulation function of PRPF6...

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Bibliographic Details
Published in:Cancer science 2020-10, Vol.111 (10), p.3665-3678
Main Authors: Song, Huijuan, Sun, Ning, Lin, Lin, Wei, Shan, Zeng, Kai, Liu, Wei, Wang, Chunyu, Zhong, Xinping, Wang, Manlin, Wang, Shengli, Zhou, Baosheng, Lv, Chi, Liu, Wensu, Zhao, Yue
Format: Article
Language:English
Subjects:
Alternative splicing
androgen receptor
Androgen receptors
Androgens
Animals
Cancer
Carcinogenesis - genetics
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
Cell cycle
Cell Line, Tumor
Cell proliferation
Cell Proliferation - genetics
Cell, Molecular, and Stem Cell Biology
Dihydrotestosterone
Dihydrotestosterone - metabolism
Epigenetics
Gene expression
Gene Expression Regulation, Neoplastic - genetics
Genomes
Hepatitis
Hepatocellular carcinoma
Heterografts
Humans
Immunohistochemistry
Kinases
Laboratories
Ligands
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Medical prognosis
Mice
Molecular modelling
mRNA processing
Original
Prostate cancer
Protein expression
Proteins
PRPF6
Receptors, Androgen - genetics
Regulatory sequences
RNA Splicing Factors - genetics
Sexual dimorphism
Signal Transduction
splicing factor
Splicing factors
Transcription
Transcription Factors - genetics
Transcriptional Activation - genetics
transcriptional regulation
Tumors
Xenografts
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