α‐hemolysin of Staphylococcus aureus impairs thrombus formation

Background Toxins are key virulence determinants of pathogens and can impair the function of host immune cells, including platelets. Insights into pathogen toxin interference with platelets will be pivotal to improve treatment of patients with bacterial bloodstream infections. Materials and Methods...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2022-06, Vol.20 (6), p.1464-1475
Main Authors: Jahn, Kristin, Handtke, Stefan, Palankar, Raghavendra, Kohler, Thomas P., Wesche, Jan, Wolff, Martina, Bayer, Janina, Wolz, Christiane, Greinacher, Andreas, Hammerschmidt, Sven
Format: Article
Language:English
Subjects:
Blood clots
Blood platelets
Calcium (intracellular)
Calcium influx
Embolization
Endocarditis
Flow cytometry
Fluorescence microscopy
Histocompatibility antigen HLA
Immunoglobulins
Intravenous administration
leukocidins
Pathogens
Phenotypes
Platelets
Pneumolysin
Staphylococcus aureus
Streptococcus infections
Thrombosis
toxins
Virulence
α‐hemolysin
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