Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that mouse Bap1 gene deletion is lethal during embryogenesis, but systemic or hematopoietic-restricted deleti...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 2012-09, Vol.337 (6101), p.1541-1546
Main Authors:	Dey, Anwesha, Seshasayee, Dhaya, Noubade, Rajkumar, French, Dorothy M., Liu, Jinfeng, Chaurushiya, Mira S., Kirkpatrick, Donald S., Pham, Victoria C., Lill, Jennie R., Bakalarski, Corey E., Wu, Jiansheng, Phu, Lilian, Katavolos, Paula, LaFave, Lindsay M., Abdel-Wahab, Omar, Modrusan, Zora, Seshagiri, Somasekar, Dong, Ken, Lin, Zhonghua, Balazs, Mercedesz, Suriben, Rowena, Newton, Kim, Hymowitz, Sarah, Garcia-Manero, Guillermo, Martin, Flavius, Levine, Ross L., Dixit, Vishva M.
Format:	Article
Language:	English
Subjects:	Animals Biological and medical sciences Bone marrow Bone marrow cells Bone Marrow Transplantation Cell Transformation, Neoplastic Chromatin Immunoprecipitation DNA Embryonic Development Embryonic growth stage Enzymes Gene Deletion Gene expression Gene Expression Regulation Gene Knock-In Techniques Genes Genes, Tumor Suppressor Genetic mutation Hematologic and hematopoietic diseases Hematopoiesis histones Host Cell Factor C1 - metabolism Humans Leukemia Leukemia, Myelomonocytic, Chronic - genetics Leukemia, Myelomonocytic, Chronic - metabolism Leukemia, Myelomonocytic, Chronic - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Melanoma Mesothelioma Mice Mice, Knockout Molecular biology Multidimensional Scaling Mutation Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - metabolism Myelodysplastic Syndromes - pathology Myeloid cells Myeloid Cells - cytology Myeloid Cells - physiology myeloid leukemia Myeloid Progenitor Cells - cytology Myeloid Progenitor Cells - physiology N-Acetylglucosaminyltransferases - metabolism Neutrophils Promoter Regions, Genetic Repressor Proteins - metabolism Spleen Stem cells Tumor Suppressor Proteins - chemistry Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors Ubiquitin Thiolesterase - chemistry Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!