NAD⁺ cleavage activity by animal and plant TIR domains in cell death pathways

SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD⁺) during Wallerian degeneration associated with neuropathies. Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize pathogen effector p...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 2019-08, Vol.365 (6455), p.793-799
Main Authors:	Horsefield, Shane, Burdett, Hayden, Zhang, Xiaoxiao, Manik, Mohammad K., Shi, Yun, Chen, Jian, Qi, Tiancong, Gilley, Jonathan, Lai, Jhih-Siang, Rank, Maxwell X., Casey, Lachlan W., Gu, Weixi, Ericsson, Daniel J., Foley, Gabriel, Hughes, Robert O., Bosanac, Todd, von Itzstein, Mark, Rathjen, John P., Nanson, Jeffrey D., Boden, Mikael, Dry, Ian B., J. Williams, Simon, Staskawicz, Brian J., Coleman, Michael P., Ve, Thomas, Dodds, Peter N., Kobe, Bostjan
Format:	Article
Language:	English
Subjects:	Adenine Animals Apoptosis Armadillo Domain Proteins - chemistry Armadillo Domain Proteins - metabolism Axons - enzymology Axons - pathology Binding Sites Cell Death Cleavage Conserved Sequence Crystal structure Crystallography, X-Ray Cytokines Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - metabolism Degeneration Depletion Enzymatic activity HEK293 Cells Humans Hypersensitive response Interleukin 1 Leucine Literary Devices Mice Mortality NAD - metabolism NAD+ Nucleosidase - chemistry NAD+ Nucleosidase - metabolism NADP NADP - metabolism NADPH-diaphorase Neurodegeneration Neurons - enzymology Neuropathy Nicotinamide Nicotinamide adenine dinucleotide Nucleotides Pathogens Plant Proteins - chemistry Plant Proteins - metabolism Protein Domains Protein Multimerization Proteins Receptors Receptors, Immunologic - chemistry Receptors, Immunologic - metabolism Ribose Self-association Signal transduction Signaling Substrates Wallerian Degeneration - enzymology Wallerian Degeneration - pathology
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!