Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity

Obesity is linked to many human diseases, including diabetes, cancer, and heart disease. There is thus great interest in understanding how genes predispose individuals to, or protect individuals from, obesity. Akbari et al. sequenced more than 600,000 exomes from the United Kingdom, the United State...

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Published in:	Science (American Association for the Advancement of Science) 2021-07, Vol.373 (6550)
Main Authors:	Akbari, Parsa, Gilani, Ankit, Sosina, Olukayode, Kosmicki, Jack A., Khrimian, Lori, Fang, Yi-Ya, Persaud, Trikaldarshi, Garcia, Victor, Sun, Dylan, Li, Alexander, Mbatchou, Joelle, Locke, Adam E., Benner, Christian, Verweij, Niek, Lin, Nan, Hossain, Sakib, Agostinucci, Kevin, Pascale, Jonathan V., Dirice, Ercument, Dunn, Michael, Kraus, William E., Shah, Svati H., Chen, Yii-Der I., Rotter, Jerome I., Rader, Daniel J., Melander, Olle, Still, Christopher D., Mirshahi, Tooraj, Carey, David J., Berumen-Campos, Jaime, Kuri-Morales, Pablo, Alegre-Díaz, Jesus, Torres, Jason M., Emberson, Jonathan R., Collins, Rory, Balasubramanian, Suganthi, Hawes, Alicia, Jones, Marcus, Zambrowicz, Brian, Murphy, Andrew J., Paulding, Charles, Coppola, Giovanni, Overton, John D., Reid, Jeffrey G., Shuldiner, Alan R., Cantor, Michael, Kang, Hyun M., Abecasis, Goncalo R., Karalis, Katia, Economides, Aris N., Marchini, Jonathan, Yancopoulos, George D., Sleeman, Mark W., Altarejos, Judith, Della Gatta, Giusy, Tapia-Conyer, Roberto, Schwartzman, Michal L., Baras, Aris, Ferreira, Manuel A. R., Lotta, Luca A.
Format:	Article
Language:	English
Subjects:	Adipose tissue Alleles Animals Basic Medicine Body Composition Body Mass Index Body size Body weight gain Brain Cardiovascular diseases Coding Coronary artery disease Diabetes mellitus Diet Energy balance Exome - genetics Gene deletion Gene mapping Genes Genetic diversity Genetic variance Genetic Variation Genetics Heart diseases High fat diet Humans Hypothalamus Inhibition Insulin Leptin Medical and Health Sciences Medical Genetics and Genomics (including Gene Therapy) Medicin och hälsovetenskap Medicinsk genetik och genomik (Här ingår: Genterapi) Medicinska och farmaceutiska grundvetenskaper Melanocortin Melanocortin MC4 receptors Meta Analysis Mice Mice, Knockout Neural coding Neuroendocrine system Obesity Obesity - genetics Polygenic inheritance Population genetics Proopiomelanocortin Proteins Receptors Receptors, G-Protein-Coupled - genetics Scientific Concepts Sequence Analysis, DNA Statistical Significance Strategy Therapeutic targets Variance analysis Weight Gain - genetics
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