Abrus precatorius Leaf Extract Reverses Alloxan/Nicotinamide-Induced Diabetes Mellitus in Rats through Hormonal (Insulin, GLP-1, and Glucagon) and Enzymatic (α-Amylase/α-Glucosidase) Modulation

Background. Abrus precatorius is used in folk medicine across Afro-Asian regions of the world. Earlier, glucose lowering and pancreato-protective effects of Abrus precatorius leaf extract (APLE) was confirmed experimentally in STZ/nicotinamide-induced diabetic rats; however, the underlying mechanism...

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Bibliographic Details
Published in:	BioMed research international 2021, Vol.2021 (1), p.9920826
Main Authors:	Boye, Alex, Barku, Victor Yao Atsu, Acheampong, Desmond Omane, Ofori, Eric Gyamerah
Format:	Article
Language:	English
Subjects:	Abrus - chemistry Abrus precatorius Acarbose Acids Alloxan alpha-Amylases - metabolism alpha-Glucosidases - metabolism Amylases Anesthesia Animals Antidiabetics Antioxidants Antioxidants - metabolism Beta cells Biomedical research Biphenyl Compounds - chemistry Blood Blood glucose Blood Glucose - metabolism Body Weight Calibration Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetic neuropathy Diabetic retinopathy Dosage Enzymatic activity Ethanol Ethnobotany Experiments Female Flavonoids Flavonoids - analysis Free Radical Scavengers - pharmacology Free radicals Glucagon Glucagon - blood Glucagon-Like Peptide 1 - blood Glucose Glucosidase Guinea Pigs Herbal medicine Herbs Hyperglycemia Inhibitory Concentration 50 Injection Insulin Insulin - blood Insulin resistance Iron - metabolism Islets of Langerhans - drug effects Islets of Langerhans - pathology Kidneys Kinetics Leaves Male Medicine Metabolism Metformin Modulation Niacinamide Nicotinamide Nitric oxide Organs Pancreas Phenols Phenols - analysis Phytochemicals - analysis Picrates - chemistry Plant extracts Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves - chemistry Rats Rats, Sprague-Dawley Scavenging Spleen Traditional medicine Weight loss α-Amylase α-Glucosidase
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