Optimising efficacy of antibiotics against systemic infection by varying dosage quantities and times

Mass production and use of antibiotics has led to the rise of resistant bacteria, a problem possibly exacerbated by inappropriate and non-optimal application. Antibiotic treatment often follows fixed-dose regimens, with a standard dose of antibiotic administered equally spaced in time. But are such...

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Bibliographic Details
Published in:PLoS computational biology 2020-08, Vol.16 (8), p.e1008037
Main Authors: Hoyle, Andy, Cairns, David, Paterson, Iona, McMillan, Stuart, Ochoa, Gabriela, Desbois, Andrew P.
Format: Article
Language:English
Subjects:
Antibiotics
Aquaculture
Artificial intelligence
Bacterial diseases
Bacterial infections
Biological models (mathematics)
Biology and Life Sciences
Communicable diseases
Control theory
Disseminated infection
Dosage
Dosage and administration
Dose-response relationship
Drug dosages
Drug metabolism
Drug resistance
Drug therapy
Experiments
Genetic algorithms
Infections
Insects
Mass production
Mathematical analysis
Mathematical models
Mathematics
Medicine and Health Sciences
Optimization
Pathogens
Pharmacodynamics
Physical Sciences
Research and Analysis Methods
Sepsis
Software
Survival
Systemic diseases
Tapering
Tuberculosis
Waterborne diseases
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