Drug Promiscuity in PDB: Protein Binding Site Similarity Is Key

Drug repositioning applies established drugs to new disease indications with increasing success. A pre-requisite for drug repurposing is drug promiscuity (polypharmacology) - a drug's ability to bind to several targets. There is a long standing debate on the reasons for drug promiscuity. Based...

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Bibliographic Details
Published in:	PloS one 2013-06, Vol.8 (6), p.e65894
Main Authors:	Haupt, V. Joachim, Daminelli, Simone, Schroeder, Michael
Format:	Article
Language:	English
Subjects:	Acarbose Acarbose - chemistry Acids Binding Sites Bioinformatics Biology Biotechnology Cancer Chemistry Correlation Databases, Protein Diabetes mellitus Drugs Flexibility Gene expression Hydrophobicity Hypoglycemic agents Kinases Ligands Medicine Methotrexate Methotrexate - chemistry Molecular weight Pharmaceutical industry Promiscuity Protein binding Protein structure Proteins Proteins - chemistry Quercetin Quercetin - chemistry Similarity Studies Trends
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