Two-Step Synthesis and Hydrolysis of Cyclic di-AMP in Mycobacterium tuberculosis

Cyclic di-AMP is a recently discovered signaling molecule which regulates various aspects of bacterial physiology and virulence. Here we report the characterization of c-di-AMP synthesizing and hydrolyzing proteins from Mycobacterium tuberculosis. Recombinant Rv3586 (MtbDisA) can synthesize c-di-AMP...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e86096
Main Authors: Manikandan, Kasi, Sabareesh, Varatharajan, Singh, Nirpendra, Saigal, Kashyap, Mechold, Undine, Sinha, Krishna Murari
Format: Article
Language:English
Subjects:
Adaptation
Adenosine diphosphate
Adenosine triphosphatase
Adenosine Triphosphate
Adenosine Triphosphate - chemistry
Allosteric Regulation
AMP
ATP
ATPases
Bacillus subtilis
Bacteria
Bacterial physiology
Bacterial Proteins
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Biochemistry, Molecular Biology
Biofilms
Biology
Biosynthesis
Cell cycle
Chemical synthesis
Chromatography
Deoxyribonucleic acid
Dinucleoside Phosphates
Dinucleoside Phosphates - biosynthesis
DNA
DNA damage
DNA repair
E coli
Escherichia coli
Gene expression
Genomics
Hydrolysis
Intermediates
Ionization
Kinases
Kinetics
Life Sciences
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Molecular biology
Mycobacterium tuberculosis
Mycobacterium tuberculosis - enzymology
Mycoplasma pneumoniae
Phosphatase
Phosphodiesterase
Phosphoric Diester Hydrolases
Phosphoric Diester Hydrolases - chemistry
Phosphorus-Oxygen Lyases
Phosphorus-Oxygen Lyases - chemistry
Phosphorus-Oxygen Lyases - genetics
Physiological aspects
Prokaryotes
Protein hydrolysates
Proteins
Signal transduction
Signaling
Streptococcus infections
Synthesis
Tuberculosis
Virulence
Virulence (Microbiology)
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