Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency

The incidence of nonalcoholic fatty liver disease (NAFLD) in postmenopausal women has increased significantly. Estrogen plays a very important role in NAFLD, but whether NAFLD in premenopausal women was caused by estrogen deficiency was unknown. Thus, it is of great clinical significance to explore...

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Published in:	PloS one 2022-02, Vol.17 (2), p.e0262855
Main Authors:	Liu, Limin, Fu, Qingsong, Li, Tiantian, Shao, Kai, Zhu, Xing, Cong, Yingzi, Zhao, Xiaoyun
Format:	Article
Language:	English
Subjects:	Access to information Adult Animals Antiinfectives and antibacterials Antimicrobial peptides Biology and Life Sciences Body weight Butyrates - metabolism Defensins Defensins - genetics Defensins - metabolism Demographic aspects Development and progression Digestive organs Digestive system Digestive tract Disease Models, Animal Estrogen Estrogens Estrogens - deficiency Estrogens - metabolism Experiments Fatty acids Fatty Acids, Volatile - metabolism Fatty liver Fecal Microbiota Transplantation Fecal microflora Feces Female Gastrointestinal Microbiome Gastrointestinal tract Gut microbiota Health aspects Hospitals Humans Intestinal microflora Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Laboratory animals Lipid metabolism Lipids Liver Liver cancer Liver diseases Medical schools Medicine Medicine and Health Sciences Metabolism Metabolites Mice Mice, Inbred C57BL Microbiota Microbiota (Symbiotic organisms) Middle Aged Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Non-alcoholic Fatty Liver Disease - therapy Oophorectomy Ovariectomy Patients Peptides Peroxisome proliferator-activated receptors Physiological aspects Post-menopause Premenopause Research and Analysis Methods Risk factors Steatosis Therapeutic targets Transplantation Triglycerides Triglycerides - blood Women Womens health Zonula occludens-1 protein Zonula Occludens-1 Protein - genetics Zonula Occludens-1 Protein - metabolism
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