Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features

The netrin‐1/DCC ligand/receptor pair has key roles in central nervous system (CNS) development, mediating axonal, and neuronal navigation. Although expression of netrin‐1 and DCC is maintained in the adult brain, little is known about their role in mature neurons. Notably, netrin‐1 is highly expres...

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Bibliographic Details
Published in:	The EMBO journal 2021-02, Vol.40 (3), p.e105537-n/a
Main Authors:	Jasmin, Mélissa, Ahn, Eun Hee, Voutilainen, Merja H, Fombonne, Joanna, Guix, Catherine, Viljakainen, Tuulikki, Kang, Seong Su, Yu, Li‐ying, Saarma, Mart, Mehlen, Patrick, Ye, Keqiang
Format:	Article
Language:	English
Subjects:	Animal models Animals Apoptosis Axonogenesis Brain Cell Death Central nervous system Cleavage DCC protein DCC Receptor - metabolism Disease Models, Animal Dopamine Dopaminergic Neurons - cytology Dopaminergic Neurons - metabolism Down-Regulation EMBO24 EMBO27 Female Gene Silencing Humans In vivo methods and tests Life Sciences Maintenance Male Mice Movement disorders Navigation behavior Netrin-1 - genetics Netrin-1 - metabolism netrin‐1/ DCC Neurobiology Neurodegenerative diseases Neurons Neurons and Cognition Neuroprotection neurorestoration Parkinson Disease - etiology Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson's disease Rats Receptors Signal Transduction Signaling Substantia nigra Substantia Nigra - cytology Substantia Nigra - metabolism
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