Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study

The systemic bioavailability of free fatty acid (FFA) forms of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) compared with ethyl ester (EE) forms is dependent on the presence of intestinal lipases and is highest during consumption of high-fat meals. Given that patients with cardiovascul...

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Bibliographic Details
Published in:	Vascular health and risk management 2013, Vol.9 (default), p.563-573
Main Authors:	Offman, Elliot, Marenco, Ted, Ferber, Sandy, Johnson, Judith, Kling, Douglas, Curcio, Danielle, Davidson, Michael
Format:	Article
Language:	English
Subjects:	Administration, Oral Area Under Curve Bioavailability Biological Availability Cardiovascular disease Care and treatment Chemistry, Pharmaceutical Cholesterol - blood Diet Diet, Fat-Restricted Dietary Supplements docosahexaenoic acid Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - adverse effects Docosahexaenoic Acids - blood Docosahexaenoic Acids - chemistry Docosahexaenoic Acids - pharmacokinetics Drug Combinations eicosapentaenoic acid Eicosapentaenoic Acid - administration & dosage Eicosapentaenoic Acid - adverse effects Eicosapentaenoic Acid - blood Eicosapentaenoic Acid - chemistry Eicosapentaenoic Acid - pharmacokinetics Esters - administration & dosage Esters - adverse effects Esters - blood Esters - chemistry Esters - pharmacokinetics Fatty acids Fatty Acids, Nonesterified - administration & dosage Fatty Acids, Nonesterified - adverse effects Fatty Acids, Nonesterified - blood Fatty Acids, Nonesterified - chemistry Fatty Acids, Nonesterified - pharmacokinetics Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - adverse effects Fatty Acids, Omega-3 - blood Fatty Acids, Omega-3 - chemistry Fatty Acids, Omega-3 - pharmacokinetics Female Health aspects Humans Hyperlipidemia hypertriglyceridemia Least-Squares Analysis Low-fat diet Male Models, Biological Original Research pharmacokinetics Statistics Triglycerides - blood
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