Isatin Counteracts Diethylnitrosamine/2-Acetylaminofluorene-Induced Hepatocarcinogenesis in Male Wistar Rats by Upregulating Anti-Inflammatory, Antioxidant, and Detoxification Pathways

Hepatocellular carcinoma (HCC) represents around 85% of all known types of liver cancers and is estimated to be the fifth most common cause of cancer-related death worldwide. The current study assessed the preventive efficacy of isatin on diethylnitrosamine (DENA)/2-acetylaminofluorene (2-AAF)-induc...

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Bibliographic Details
Published in:	Antioxidants 2022-04, Vol.11 (4), p.699
Main Authors:	Tawfik, Nagwa G., Mohamed, Wafaa R., Mahmoud, Hanan S., Alqarni, Mohammed A., Naguib, Ibrahim A., Fahmy, Alzhraa M., Ahmed, Osama M.
Format:	Article
Language:	English
Subjects:	acetylaminofluorene Animals Antioxidants Apoptosis Bilirubin Biomarkers Biotechnology Cancer therapies Caspase-3 Chemotherapy Detoxification Diethylnitrosamine Experiments Glutathione Glutathione transferase Hepatocellular carcinoma Inflammation isatin Lipid peroxidation Liver Membranes Molecular modelling NAD NF-κB protein Oral administration Oxidative stress Oxidoreductase Proteins Quinine Rodents Serum levels Signal transduction Superoxide dismutase Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors Variance analysis
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