Aging, Cellular Senescence, and Alzheimer’s Disease

Aging is the greatest risk factor for late-onset Alzheimer’s disease (LOAD), which accounts for >95% of Alzheimer’s disease (AD) cases. The mechanism underlying the aging-related susceptibility to LOAD is unknown. Cellular senescence, a state of permanent cell growth arrest, is believed to contri...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-02, Vol.23 (4), p.1989
Main Author: Liu, Rui-Ming
Format: Article
Language:English
Subjects:
Age
Aging
Aging - pathology
Alzheimer Disease - pathology
Alzheimer's disease
Animals
Apoptosis
Astrocytes - pathology
Brain - pathology
Cancer
Cell cycle
Cell growth
Cellular Senescence - physiology
Cyclin-dependent kinases
DNA damage
Humans
Hypotheses
Kinases
Musculoskeletal system
Neurons - pathology
Oxidative stress
Pathophysiology
Physiology
Proteins
Review
Rodents
Senescence
Stem cells
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