The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF-κB To Dampen NF-κB–Stimulated Gene Transcription

Full-length IL-33 is a member of the IL-1 family of cytokines, which can act in an autocrine or paracrine manner by binding to the IL-33R on several different target cell types. In addition, IL-33 can act in an intracrine fashion by translocating to the nucleus, where it binds to the chromatin and m...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2011-08, Vol.187 (4), p.1609-1616
Main Authors: Ali, Shafaqat, Mohs, Antje, Thomas, Meike, Klare, Jan, Ross, Ralf, Schmitz, Michael Lienhard, Martin, Michael Uwe
Format: Article
Language:English
Subjects:
Animals
HEK293 Cells
Humans
Interleukin-18 - genetics
Interleukin-18 - immunology
Interleukin-18 - metabolism
Interleukin-1beta - genetics
Interleukin-1beta - immunology
Interleukin-1beta - metabolism
Interleukin-33
Interleukins - genetics
Interleukins - immunology
Interleukins - metabolism
Mast Cells - immunology
Mast Cells - metabolism
Mice
NF-kappa B p50 Subunit - genetics
NF-kappa B p50 Subunit - immunology
NF-kappa B p50 Subunit - metabolism
Th2 Cells - immunology
Th2 Cells - metabolism
Transcription Factor RelA - genetics
Transcription Factor RelA - immunology
Transcription Factor RelA - metabolism
Transcription, Genetic - genetics
Transcription, Genetic - immunology
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