Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Renal Dysfunction: The ROSE Acute Heart Failure Randomized Trial

IMPORTANCE Small studies suggest that low-dose dopamine or low-dose nesiritide may enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction; however, neither strategy has been rigorously tested. OBJECTIVE To test the 2 independent hypotheses that, c...

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Published in:	JAMA : the journal of the American Medical Association 2013-12, Vol.310 (23), p.2533-2543
Main Authors:	Chen, Horng H, Anstrom, Kevin J, Givertz, Michael M, Stevenson, Lynne W, Semigran, Marc J, Goldsmith, Steven R, Bart, Bradley A, Bull, David A, Stehlik, Josef, LeWinter, Martin M, Konstam, Marvin A, Huggins, Gordon S, Rouleau, Jean L, O'Meara, Eileen, Tang, W. H. Wilson, Starling, Randall C, Butler, Javed, Deswal, Anita, Felker, G. Michael, O'Connor, Christopher M, Bonita, Raphael E, Margulies, Kenneth B, Cappola, Thomas P, Ofili, Elizabeth O, Mann, Douglas L, Dávila-Román, Víctor G, McNulty, Steven E, Borlaug, Barry A, Velazquez, Eric J, Lee, Kerry L, Shah, Monica R, Hernandez, Adrian F, Braunwald, Eugene, Redfield, Margaret M
Format:	Article
Language:	English
Subjects:	Acute Disease Aged Aged, 80 and over Biological and medical sciences Cardiology. Vascular system Clinical outcomes Cystatin C - blood Diuretics - therapeutic use Dopamine - administration & dosage Double-Blind Method Drug dosages Drug Therapy, Combination Female General aspects Glomerular Filtration Rate Heart Heart failure Heart Failure - complications Heart Failure - drug therapy Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Kidney - physiopathology Kidney diseases Kidney Diseases - complications Kidney Diseases - drug therapy Male Medical sciences Middle Aged Natriuretic Agents - administration & dosage Natriuretic Peptide, Brain - administration & dosage Nephrology Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Neurotransmitters Renal failure Treatment Outcome Urine Vasodilator Agents - administration & dosage
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