Effect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial

Concurrent chemoradiotherapy has been the standard treatment for stage II nasopharyngeal carcinoma (NPC) based on data using 2-dimensional conventional radiotherapy. There is limited evidence for the role of chemotherapy with use of intensity-modulated radiation therapy (IMRT). To assess whether con...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2022-08, Vol.328 (8), p.728-736
Main Authors: Tang, Ling-Long, Guo, Rui, Zhang, Ning, Deng, Bin, Chen, Lei, Cheng, Zhi-Bin, Huang, Jing, Hu, Wei-Han, Huang, Shao Hui, Luo, Wei-Jun, Liang, Jin-Hui, Zheng, Yu-Ming, Zhang, Fan, Mao, Yan-Ping, Li, Wen-Fei, Zhou, Guan-Qun, Liu, Xu, Chen, Yu-Pei, Xu, Cheng, Lin, Li, Liu, Qing, Du, Xiao-Jing, Zhang, Yuan, Sun, Ying, Ma, Jun
Format: Article
Language:English
Subjects:
Adult
Adverse events
Anorexia
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Appetite loss
Body weight loss
Cancer
Chemoradiotherapy
Chemoradiotherapy - adverse effects
Chemoradiotherapy - methods
Chemotherapy
Cisplatin
Cisplatin - administration & dosage
Cisplatin - adverse effects
Clinical trials
Constipation
DNA viruses
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Female
Global health
Health services
Herpesvirus 4, Human
Humans
Insomnia
Leukopenia
Male
Metastases
Metastasis
Middle Aged
Mucositis
Nasopharyngeal carcinoma
Nasopharyngeal Carcinoma - drug therapy
Nasopharyngeal Carcinoma - etiology
Nasopharyngeal Carcinoma - pathology
Nasopharyngeal Carcinoma - radiotherapy
Nasopharyngeal Neoplasms - drug therapy
Nasopharyngeal Neoplasms - etiology
Nasopharyngeal Neoplasms - pathology
Nasopharyngeal Neoplasms - radiotherapy
Nausea
Neutropenia
Nodes
Original Investigation
Pain
Patients
Public health
Quality of Life
Radiation
Radiation therapy
Radiotherapy, Intensity-Modulated - adverse effects
Radiotherapy, Intensity-Modulated - methods
Randomization
Risk
Signs and symptoms
Sleep disorders
Survival
Throat cancer
Toxicity
Vomiting
Weight loss
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