Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial

IMPORTANCE: Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical aortic valve replacement and is the treatment of choice for patients at high operative risk. The role of TAVI in patients at lower risk is unclear. OBJECTIVE: To determine whether TAVI is noninferio...

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Published in:	JAMA : the journal of the American Medical Association 2022-05, Vol.327 (19), p.1875-1887
Main Authors:	Toff, William D, Hildick-Smith, David, Kovac, Jan, Mullen, Michael J, Wendler, Olaf, Mansouri, Anita, Rombach, Ines, Abrams, Keith R, Conroy, Simon P, Flather, Marcus D, Gray, Alastair M, MacCarthy, Philip, Monaghan, Mark J, Prendergast, Bernard, Ray, Simon, Young, Christopher P, Crossman, David C, Cleland, John G. F, de Belder, Mark A, Ludman, Peter F, Jones, Stephen, Densem, Cameron G, Tsui, Steven, Kuduvalli, Manoj, Mills, Joseph D, Banning, Adrian P, Sayeed, Rana, Hasan, Ragheb, Fraser, Douglas G. W, Trivedi, Uday, Davies, Simon W, Duncan, Alison, Curzen, Nick, Ohri, Sunil K, Malkin, Christopher J, Kaul, Pankaj, Muir, Douglas F, Owens, W. Andrew, Uren, Neal G, Pessotto, Renzo, Kennon, Simon, Awad, Wael I, Khogali, Saib S, Matuszewski, Maciej, Edwards, Richard J, Ramesh, Bandigowdanapalya C, Dalby, Miles, Raja, Shahzad G, Mariscalco, Giovanni, Lloyd, Clinton, Cox, Ian D, Redwood, Simon R, Gunning, Mark G, Ridley, Paul D
Format:	Article
Language:	English
Subjects:	Aged Aged, 80 and over Aorta Aortic stenosis Aortic valve Aortic Valve - surgery Aortic Valve Insufficiency - etiology Aortic Valve Stenosis - mortality Aortic Valve Stenosis - surgery Bleeding Clinical trials Complications Conduction Fatalities Female Heart Valve Prosthesis Heart Valve Prosthesis Implantation - adverse effects Heart Valve Prosthesis Implantation - methods Heart Valve Prosthesis Implantation - mortality Heart valves Humans Implantation Male Mortality Original Investigation Pacemakers Patients Regurgitation Risk Risk Factors Surgery Thorax Transcatheter Aortic Valve Replacement - adverse effects Transcatheter Aortic Valve Replacement - mortality Transplants & implants Treatment Outcome
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