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Nanovaccine Showing Potent Immunotherapy to Tumor by Activating Γ δ T Cells
Most vaccines are designed to attack tumor cells by activating CD4 + /CD8 + αβ T cells. Unfortunately, αβ T cells, which only recognize the peptide antigens in the complexes with polymorphic MHCI/II molecules, surrender to the tumor heterogenicity. As another subset of T cells, γδ T cells become sal...
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Published in: | Advanced functional materials 2023-10, Vol.33 (44) |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Most vaccines are designed to attack tumor cells by activating CD4
+
/CD8
+
αβ
T cells. Unfortunately,
αβ
T cells, which only recognize the peptide antigens in the complexes with polymorphic MHCI/II molecules, surrender to the tumor heterogenicity. As another subset of T cells,
γδ
T cells become salient in antitumor because of their unique immunotherapeutic roles. Herein, a tumor vaccine is developed with multivalent antigens by fusion of tumor cell membranes with lipids and successfully activated
γδ
T cells via microneedle inoculation. It is certified that the evoked
γδ
T cells synchronize with
αβ
T cells revitalizing tumor‐induced immunotolerance. In turn, the tumors of mice are significantly inhibited and their median survival time is prolonged considerably. Moreover, the nanovaccine inhibits tumor recurrence after resection. The therapeutic effects are corroborated with the results from TCR
δ
−/−
mice as well as cytokine expression in tumor. |
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ISSN: | 1616-301X 1616-3028 |
DOI: | 10.1002/adfm.202303537 |