Iridium-Catalyzed Enantioselective Hydrogenation of Olefins

Cationic iridium complexes with chiral P,N‐ligands and tetrakis[3,5‐(trifluoromethyl)phenyl]borate (BArF) as the counterion are efficient homogeneous catalysts for the enantioselective hydrogenation of olefins. The complexes are readily prepared, air‐stable, and easy to handle. In contrast to chiral...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2003-01, Vol.345 (1-2), p.33-43
Main Authors: Pfaltz, Andreas, Blankenstein, Jörg, Hilgraf, Robert, Hörmann, Esther, McIntyre, Steven, Menges, Frederik, Schönleber, Marc, Smidt, Sebastian P., Wüstenberg, Bettina, Zimmermann, Nicole
Format: Article
Language:English
Subjects:
alkenes
asymmetric hydrogenation
iridium
N,P‐ligands
oxazolines
P-ligands
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Summary:Cationic iridium complexes with chiral P,N‐ligands and tetrakis[3,5‐(trifluoromethyl)phenyl]borate (BArF) as the counterion are efficient homogeneous catalysts for the enantioselective hydrogenation of olefins. The complexes are readily prepared, air‐stable, and easy to handle. In contrast to chiral rhodium‐ and ruthenium‐phosphine catalysts, they do not require the presence of a polar coordinating group near the CC bond. In the hydrogenation of unfunctionalized arylolefins, high enantioselectivities of >95% ee with turnover numbers of up to 5000 and turnover frequencies of >5000 h−1 have been achieved.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200390027