Cu(II)‐Mediated C−C/C−O Bond Formation via C−H/C−C Bond Cleavage: Access to Benzofurans Using Amide as a Traceless Directing Group

A copper‐mediated synthesis of 2,3‐disubstituted benzofurans with the assistance of an 8‐aminoquinolyl auxiliary is described from readily available benzamides and benzoylacetonitriles. In this reaction, the C−C bond is successfully constructed via C−H activation, and C−O bond is subsequently formed...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2020-01, Vol.362 (1), p.118-125
Main Authors: Yu, Shuling, Lv, Ningning, Liu, Zhanxiang, Zhang, Yuhong
Format: Article
Language:English
Subjects:
Ammonia
benzofurans synthesis
cascade reaction
chemoselectivity
Cleavage
Copper
C−H activation
traceless directing group
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