Morbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis

It is not clear why some methamphetamine (MAMP) abusers develop psychotic symptoms, while others use MAMP regularly over long periods and remain unscathed. We tested the hypotheses that those users who develop MAMP‐induced psychosis (MIP) have greater familial loading for psychotic disorders than us...

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Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2005-07, Vol.136B (1), p.87-91
Main Authors: Chen, Chih-Ken, Lin, Shih-Ku, Sham, Pak C., Ball, David, Loh, El-Wui, Murray, Robin M.
Format: Article
Language:English
Subjects:
Adult
amphetamine
Amphetamine-Related Disorders - epidemiology
Amphetamine-Related Disorders - genetics
Comorbidity
familial risk
Family
Female
genetic disposition
Humans
Interviews as Topic
Male
Mental Disorders - genetics
Methamphetamine - poisoning
Prevalence
psychosis
Psychotic Disorders - epidemiology
Psychotic Disorders - etiology
Risk Factors
schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
substance abuse
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container_title American journal of medical genetics. Part B, Neuropsychiatric genetics
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creator Chen, Chih-Ken
Lin, Shih-Ku
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Loh, El-Wui
Murray, Robin M.
description It is not clear why some methamphetamine (MAMP) abusers develop psychotic symptoms, while others use MAMP regularly over long periods and remain unscathed. We tested the hypotheses that those users who develop MAMP‐induced psychosis (MIP) have greater familial loading for psychotic disorders than users with no psychosis. Four hundred forty‐five MAMP users were recruited from a psychiatric hospital and a detention center in Taipei, and were assessed with the Diagnostic Interview for genetic studies (DIGS‐C) and the Family Interview for genetic study (FIGS‐C). Morbid risk (MR) for psychiatric disorders in first‐degree relatives was compared between those MAMP users with a lifetime diagnosis of MAMP psychosis and those without. The relatives of MAMP users with a lifetime diagnosis of MAMP psychosis had a significantly higher MR for schizophrenia (OR = 5.4, 95% CI: 2.0–14.7, P 
doi_str_mv 10.1002/ajmg.b.30187
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We tested the hypotheses that those users who develop MAMP‐induced psychosis (MIP) have greater familial loading for psychotic disorders than users with no psychosis. Four hundred forty‐five MAMP users were recruited from a psychiatric hospital and a detention center in Taipei, and were assessed with the Diagnostic Interview for genetic studies (DIGS‐C) and the Family Interview for genetic study (FIGS‐C). Morbid risk (MR) for psychiatric disorders in first‐degree relatives was compared between those MAMP users with a lifetime diagnosis of MAMP psychosis and those without. The relatives of MAMP users with a lifetime diagnosis of MAMP psychosis had a significantly higher MR for schizophrenia (OR = 5.4, 95% CI: 2.0–14.7, P &lt; 0.001) than the relatives of those probands who never became psychotic. Furthermore, the MR for schizophrenia in the relatives of the subjects with a prolonged MAMP psychosis (MIP‐P) was higher than in the relatives of those users with a brief MAMP psychosis (MIP‐B) (OR = 2.8, 95% CI: 1.0–8.0, P = 0.042). 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The relatives of MAMP users with a lifetime diagnosis of MAMP psychosis had a significantly higher MR for schizophrenia (OR = 5.4, 95% CI: 2.0–14.7, P &lt; 0.001) than the relatives of those probands who never became psychotic. Furthermore, the MR for schizophrenia in the relatives of the subjects with a prolonged MAMP psychosis (MIP‐P) was higher than in the relatives of those users with a brief MAMP psychosis (MIP‐B) (OR = 2.8, 95% CI: 1.0–8.0, P = 0.042). 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source Wiley-Blackwell Read & Publish Collection
subjects Adult
amphetamine
Amphetamine-Related Disorders - epidemiology
Amphetamine-Related Disorders - genetics
Comorbidity
familial risk
Family
Female
genetic disposition
Humans
Interviews as Topic
Male
Mental Disorders - genetics
Methamphetamine - poisoning
Prevalence
psychosis
Psychotic Disorders - epidemiology
Psychotic Disorders - etiology
Risk Factors
schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
substance abuse
title Morbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis
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