Magnesium Corrosion Triggered Spontaneous Generation of H 2 O 2 on Oxidized Titanium for Promoting Angiogenesis

Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system th...

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Published in:Angewandte Chemie International Edition 2015-12, Vol.54 (49), p.14753-14757
Main Authors: Park, Jimin, Du, Ping, Jeon, Jin‐Kyung, Jang, Gun Hyuk, Hwang, Mintai Peter, Han, Hyung‐Seop, Park, Kwideok, Lee, Kwan Hyi, Lee, Jee‐Wook, Jeon, Hojeong, Kim, Yu‐Chan, Park, Jong Woong, Seok, Hyun‐Kwang, Ok, Myoung‐Ryul
Format: Article
Language:English
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Summary:Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H 2 O 2 without any external light or voltage. The corrosion of Mg transfers electrons to Au‐decorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H 2 O 2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H 2 O 2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201507352