Back Cover: Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles (Angew. Chem. Int. Ed. 27/2019)

Highly stable tetrazines that react rapidly with isonitriles are presented by R. M. Franzini et al. in their Communication on page 9043 ff. Bulky tetrazine substituents sterically attract the isocyano group in the cycloaddition transition state and block the approach of strained alkenes. These chara...

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Published in:Angewandte Chemie International Edition 2019-07, Vol.58 (27), p.9290-9290
Main Authors: Tu, Julian, Svatunek, Dennis, Parvez, Saba, Liu, Albert C., Levandowski, Brian J., Eckvahl, Hannah J., Peterson, Randall T., Houk, Kendall N., Franzini, Raphael M.
Format: Article
Language:English
Subjects:
bioconjugation
bioorthogonal chemistry
chemoselectivity
cycloadditions
dispersion forces
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container_issue 27
container_start_page 9290
container_title Angewandte Chemie International Edition
container_volume 58
creator Tu, Julian
Svatunek, Dennis
Parvez, Saba
Liu, Albert C.
Levandowski, Brian J.
Eckvahl, Hannah J.
Peterson, Randall T.
Houk, Kendall N.
Franzini, Raphael M.
description Highly stable tetrazines that react rapidly with isonitriles are presented by R. M. Franzini et al. in their Communication on page 9043 ff. Bulky tetrazine substituents sterically attract the isocyano group in the cycloaddition transition state and block the approach of strained alkenes. These characteristics enable rapid bioorthogonal labeling and release reactions and allow for triple‐orthogonal protein labeling.
doi_str_mv 10.1002/anie.201906875
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subjects bioconjugation
bioorthogonal chemistry
chemoselectivity
cycloadditions
dispersion forces
title Back Cover: Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles (Angew. Chem. Int. Ed. 27/2019)
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