Structure and in vitro antifungal activity of [2,6-bis(dimethylaminomethyl)phenyl]diphenyltin(IV) compounds

A set of seven [2,6‐bis(dimethylaminomethyl)phenyl]diphenyltin(IV) ({[(CH3)2NCH2]2(C6H3)}­(C6H5)2Sn+X−) ionic organotin(IV) compounds (X = Br, NO3, CN, SCN, SeCN, BF4 and PF6) has been prepared and characterized by electrospray ionization mass spectrometry, 1H NMR spectroscopy in CDCl3,119Sn NMR in...

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Published in:Applied organometallic chemistry 2002-06, Vol.16 (6), p.315-322
Main Authors: Růžic̆ka, Aleš, Dostál, Libor, Jambor, Roman, Buchta, Vladimír, Brus, Jir̆í, Císar̆ová, Ivana, Holc̆apek, Michal, Holec̆ek, Jaroslav
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Biological and medical sciences
CP/MAS NMR spectroscopy
ESI mass spectrometry
in vitro antifungal screening
Medical sciences
N, C, N‐ligand
N-ligand
NMR spectroscopy
Pharmacology. Drug treatments
water-soluble organotin(IV) compounds
X-ray diffraction
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Summary:A set of seven [2,6‐bis(dimethylaminomethyl)phenyl]diphenyltin(IV) ({[(CH3)2NCH2]2(C6H3)}­(C6H5)2Sn+X−) ionic organotin(IV) compounds (X = Br, NO3, CN, SCN, SeCN, BF4 and PF6) has been prepared and characterized by electrospray ionization mass spectrometry, 1H NMR spectroscopy in CDCl3,119Sn NMR in CDCl3 and DMSO‐d6 solution, as well as by 13C and 119Sn CP/MAS NMR spectroscopy and X‐ray diffraction techniques in the solid state. The in vitro antifungal activity of these water‐soluble ionic organotin(IV) compounds was compared with starting compounds and the antifungal drugs currently in clinical use. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.302