role of ATF-2 in oncogenesis

Activating Transcription Factor-2 is a sequence-specific DNA-binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c-jun, which are involved in...

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Bibliographic Details
Published in:BioEssays 2008-04, Vol.30 (4), p.314-327
Main Authors: Vlahopoulos, Spiros A, Logotheti, Stella, Mikas, Dimitris, Giarika, Athina, Gorgoulis, Vassilis, Zoumpourlis, Vassilis
Format: Article
Language:English
Subjects:
Activating Transcription Factor 2 - genetics
Activating Transcription Factor 2 - metabolism
Activating Transcription Factor 2 - physiology
Animals
Apoptosis
Cell Adhesion
Cell Line, Tumor
Cell Transformation, Neoplastic
Dimerization
DNA-Binding Proteins - metabolism
Humans
Mice
Models, Biological
Models, Genetic
Neoplasms - metabolism
Signal Transduction
Transcription Factors - metabolism
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Summary:Activating Transcription Factor-2 is a sequence-specific DNA-binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c-jun, which are involved in oncogenesis in various tissue types. ATF-2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for ATF-2. In this review, we summarize the signaling pathways that activate ATF-2, as well as its downstream targets. We examine the role of ATF-2 in carcinogenesis with respect to other bZIP proteins, using data from studies in human cancer cell lines, human tumours and mouse models, and we propose a potential model for its function in carcinogenesis, as well as a theoretical basis for its utility in anticancer drug design. BioEssays 30:314-327, 2008.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.20734