SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation

The aging process involves changes in immune regulation, i.e. adaptive immunity declines whereas innate immunity becomes activated. NF-κB signaling is the master regulator of the both immune systems. Two recent articles highlight the role of the NF-κB system in aging and immune responses. Adler et a...

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Bibliographic Details
Published in:BioEssays 2008-10, Vol.30 (10), p.939-942
Main Authors: Salminen, Antero, Kauppinen, Anu, Suuronen, Tiina, Kaarniranta, Kai
Format: Article
Language:English
Subjects:
acetylation
adaptive immunity
HIV infections
Human immunodeficiency virus 1
immune response
immune system
immunosuppression
inflammation
innate immunity
longevity
transcription factor NF-kappa B
transcriptional activation
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