Development and qualification of 3 L scale‐down model for large scale vaccine process on Vero cell culture using microcarriers

Scale‐down models (SDM) are pivotal tools for process understanding and improvement to accelerate the development of vaccines from laboratory research to global commercialization. In this study, a 3 L SDM representing a 50 L scale Vero cell culture process of a live‐attenuated virus vaccine using mi...

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Bibliographic Details
Published in:	Biotechnology and bioengineering 2024-11, Vol.121 (11), p.3402-3414
Main Authors:	Huang, Renjing, Wang, Kai, Flamm, Matthew H., Vazquez, Jorge, Gercke, Chris, Ton, Christopher, Whitmer, Travis, Mathis, Pamela K., Ploeger, Kristin J. M., Rameez, Shahid
Format:	Article
Language:	English
Subjects:	cell culture computational fluid dynamics multivariate data analysis process characterization scale‐down model Vero cells
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