Demonstrating the Effectiveness of an Alternative to Triton X‐100 for Detergent‐Mediated Viral Inactivation in Biomanufacturing

Detergent‐mediated viral inactivation is an important process step for ensuring viral safety of parenteral biotherapeutics, including plasma proteins and monoclonal antibodies (mAb). The conventional Triton X‐100 detergent has ecological toxicity concerns and REACH classification that mandate replac...

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Bibliographic Details
Published in:Biotechnology and bioengineering 2025-05, Vol.122 (5), p.1087-1095
Main Authors: Banerjee, Kakolie, Antonello, Alice, Johnson, Sandra, Licht, Anja, Rapp, Almut, Miller, Corinne
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biodegradation
Cell culture
Deactivation
Detergents
Detergents - chemistry
Detergents - pharmacology
Effectiveness
GMP‐compliant detergent
Humans
Immunoglobulin G
Inactivation
Industrial safety
Micelles
Monoclonal antibodies
Octoxynol - pharmacology
parenteral drug safety
Plasma proteins
Protein A
Proteins
REACH‐compliant detergent
Resins
Toxicity
Triton X‐100 replacement
viral inactivation
Virus Inactivation - drug effects
Viruses - drug effects
Citations: Items that this one cites
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