Performance characteristics of an analytical procedure for determining chloramphenicol residues in muscle tissue by gas chromatography-electron capture detection

Validation of an analytical method for determining chloramphenicol residues in muscle tissue by gas chromatography–electron capture detection (GC‐ECD) was performed according to the latest European Union criteria for the analysis of veterinary drugs in food, laid down by Commission Decision 2002/657...

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Bibliographic Details
Published in:Biomedical chromatography 2006-10, Vol.20 (10), p.985-992
Main Author: Cerkvenik-Flajs, Vesna
Format: Article
Language:English
Subjects:
Animals
antibiotics
chloramphenicol
Chloramphenicol - analysis
Chromatography, Gas - methods
Drug Residues - analysis
Food Analysis - methods
gas chromatography
Humans
Meat Products - analysis
Molecular Structure
muscle tissue
Reproducibility of Results
residue analysis
validation
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Summary:Validation of an analytical method for determining chloramphenicol residues in muscle tissue by gas chromatography–electron capture detection (GC‐ECD) was performed according to the latest European Union criteria for the analysis of veterinary drugs in food, laid down by Commission Decision 2002/657/EC. The method using the meta isomer of chloramphenicol as an internal standard proved to be very selective, specific to other related phenicols and accurate to within +3.6% at a concentration level of 8.9 µg/kg, as present in the certified reference material available. The correlation coefficient of the calibration curve was 0.9991. At all three fortification levels studied (0.3, 0.45 and 0.6 µg/kg), repeatability and intra‐laboratory reproducibility were
ISSN:0269-3879
1099-0801
DOI:10.1002/bmc.599