Front Cover: Biosynthesis of the Isocoumarin Derivatives Fusamarins is Mediated by the PKS8 Gene Cluster in Fusarium (ChemBioChem 6/2023)

Fusaria are plant‐pathogens known to produce various secondary metabolites (SMs). Yet, the majority of them is still cryptic due to low production levels in axenic culture, and even less are assigned to their respective biosynthetic gene cluster (BGC). Expression of such greatly depends on the chrom...

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Published in:Chembiochem : a European journal of chemical biology 2023-03, Vol.24 (6), p.n/a
Main Authors: Atanasoff‐Kardjalieff, Anna K., Seidl, Bernhard, Steinert, Katharina, Daniliuc, Constantin G., Schuhmacher, Rainer, Humpf, Hans‐Ulrich, Kalinina, Svetlana, Studt‐Reinhold, Lena
Format: Article
Language:English
Subjects:
dihydroisocoumarins
Fusarium fujikuroi species complex (FFSC)
heterochromatin
polyketides
secondary metabolites
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Summary:Fusaria are plant‐pathogens known to produce various secondary metabolites (SMs). Yet, the majority of them is still cryptic due to low production levels in axenic culture, and even less are assigned to their respective biosynthetic gene cluster (BGC). Expression of such greatly depends on the chromatin structure that determines the accessibility of the associated DNA. Genetic manipulation of the histone H3K9‐trimethyltransferase revealed the isocoumarin derivatives fusamarins, and allowed to assign these SMs to the respective BGC. Cover art by Christina Maisl (Farphyni). More information can be found in the Research Article by Lena Studt‐Reinhold et al.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202200773