Total Synthesis of (R,R,R)-α-Tocopherol Through Asymmetric Cu-Catalyzed 1,4-Addition

By introducing a disposable activating substituent at C‐3, the asymmetric 1,4‐addition to a notoriously unreactive 2‐substituted chromenone was achieved with high levels of (2R)‐stereoselectivity in the presence of a chiral CuI‐phosphoramidite complex as a catalyst. This paved the way for an efficie...

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Bibliographic Details
Published in:Chemistry : a European journal 2014-09, Vol.20 (38), p.12051-12055
Main Authors: Termath, Andreas Ole, Sebode, Hanna, Schlundt, Waldemar, Stemmler, René T., Netscher, Thomas, Bonrath, Werner, Schmalz, Hans-Günther
Format: Article
Language:English
Subjects:
alpha-Tocopherol - chemical synthesis
alpha-Tocopherol - chemistry
asymmetric conjugate addition
Asymmetry
Catalysis
Catalysts
chiral ligands
chromenones
Copper
Copper - chemistry
copper catalysis
Esters
Level (quantity)
Molecular Structure
Stereoisomerism
Synthesis
Tocopherol
vitamin E
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