Unexpected efficiency of non‐ C 2 ‐symmetric bis(hydroxyamide)‐based zinc‐chelate catalysts

Asymmetric bis(hydroxyamide)‐based zinc‐chelate catalysts are able to promote the enantioselective addition of diethylzinc to benzaldehyde in the absence of titanium with yields and ee s comparable, or inclusively superior, to their C 2 ‐symmetric analogues. This unexpected fact demonstrates that th...

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Published in:Chirality (New York, N.Y.) N.Y.), 2011-08, Vol.23 (7), p.523-526
Main Authors: Sánchez‐Carnerero, Esther M. Márquez, de las Casas Engel, Tomás, Lora Maroto, Beatriz, de la Moya Cerero, Santiago
Format: Article
Language:English
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Summary:Asymmetric bis(hydroxyamide)‐based zinc‐chelate catalysts are able to promote the enantioselective addition of diethylzinc to benzaldehyde in the absence of titanium with yields and ee s comparable, or inclusively superior, to their C 2 ‐symmetric analogues. This unexpected fact demonstrates that the previously established assumption on the necessity of using C 2 ‐symmetric bis(hydrdoxyamides) to generate C 2 ‐symmetric zinc‐chelate catalysts can be discarded, which expand the possibilities for designing new ligands based on the interesting hydroxyl‐amide functional grouping. Chirality, 2011. © 2011 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.20958