An Efficient α-Alkylation of Aromatic Ketones with Primary Alcohols Catalyzed by [Cp＊IrCI2]2 without Solvent

Aromatic ketones are directly alkylated at a position with primary alcohols at 110 ℃ in the presence of catalytic amount of KOH and [Cp＊lrC12]2 （Cp＊=pentamethylcyclopentadienyl） catalyst. The reaction is carried out in the absence of any solvent or additive, which generates only water as the byprodu...

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Bibliographic Details
Published in:Chinese journal of chemistry 2012-10, Vol.30 (10), p.2363-2366
Main Author: 李剑 张卫星 王锋 江敏 董肖椿 赵伟利
Format: Article
Language:English
Subjects:
aldol condensation
carbon-carbon δ-bond formation
iridium catalyzed hydrogen transfer
KOH
solvent-free
α-alkylation of ketones
伯醇
催化剂
无溶剂
烷基化
甲基环戊二烯基
缩合工艺
芳香酮
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Summary:Aromatic ketones are directly alkylated at a position with primary alcohols at 110 ℃ in the presence of catalytic amount of KOH and [Cp＊lrC12]2 （Cp＊=pentamethylcyclopentadienyl） catalyst. The reaction is carried out in the absence of any solvent or additive, which generates only water as the byproduct in theory. It is very efficient and generally completed in 10 min in good isolated yields. The reaction is believed to undergo successive hydrogen transfer and cross aldol condensation processes.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201200524